Steve has been working in the Oxford Glycobiology Institute for a number of years and is currently interested in all aspects of the Hepatitis C virus (HCV) lifecycle. He is currently following up a number of interesting avenues brought to light from a gene and protein analysis of changes in host cells upon HCV infection. In addition he manages a number of things in the lab.
Woodhouse SD, Narayan R, Latham S, Lee S, Antrobus R, Gangadharan B, Luo S, Schroth GP, Klenerman P, Zitzmann N, Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro, Hepatology. 2010;52(2):443-53.
Woodhouse SD, Smith C, Michelet M, Branza-Nichita N, Hussey M, Dwek RA, Zitzmann N, Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells, Antimicrob Agents Chemother. 2008;52(5):1820-8.
Pavlovic D, Fischer W, Hussey M, Durantel D, Durantel S, Branza-Nichita N, Woodhouse S, Dwek RA, Zitzmann N, Long alkylchain iminosugars block the HCV p7 ion channel, Adv Exp Med Biol. 2005;564:3-4.
Also from a previous non-virology based existence
Down RE, Ford L, Woodhouse SD, Davison GM, Majerus ME, Gatehouse JA, Gatehouse AM, Tritrophic interactions between transgenic potato expressing snowdrop lectin (GNA), an aphid pest (peach-potato aphid; Myzus persicae (Sulz.) and a beneficial predator (2-spot ladybird; Adalia bipunctata L.), Transgenic Res. 2003;12(2):229-41.
Fitches E, Woodhouse SD, Edwards JP, Gatehouse JA, In vitro and in vivo binding of snowdrop (Galanthus nivalis agglutinin; GNA) and jackbean (Canavalia ensiformis; Con A) lectins within tomato moth (Lacanobia oleracea) larvae; mechanisms of insecticidal action, J Insect Physiol. 2001;47(7):777-787.
Down RE, Ford L, Woodhouse SD, Raemaekers RJ, Leitch B, Gatehouse JA, Gatehouse AM, Snowdrop lectin (GNA) has no acute toxic effects on a beneficial insect predator, the 2-spot ladybird (Adalia bipunctata L.), J Insect Physiol. 2000;46(4):379-391.