Collaborators List

 

Eleanor Barnes

Gangadharan, B., M. Bapat, J. Rossa, R. Antrobus, D. Chittenden, B. Kampa, E. Barnes, P. Klenerman, R.A. Dwek and N. Zitzmann, Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study, PLoS One, 2012, 7 (6): p. e39603.

 

Gangadharan, B., R. Antrobus, D. Chittenden, J. Rossa, M. Bapat, P. Klenerman, E. Barnes, R.A. Dwek and N. Zitzmann, New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients, J Proteome Res, 2011, 10 (5): p. 2643-2650.

 

Billerbeck, E., Y.H. Kang, L. Walker, H. Lockstone, S. Grafmueller, V. Fleming, J. Flint, C.B. Willberg, B. Bengsch, B. Seigel, N. Ramamurthy, N. Zitzmann, E.J. Barnes, J. Thevanayagam, A. Bhagwanani, A. Leslie, Y.H. Oo, S. Kollnberger, P. Bowness, O. Drognitz, D.H. Adams, H.E. Blum, R. Thimme and P. Klenerman, Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties, Proc Natl Acad Sci U S A, 2010, 107 (7): p. 3006-3011.

 


Ralf Bartenschlager

Steinmann, E., T. Whitfield, S. Kallis, R.A. Dwek, N. Zitzmann, T. Pietschmann and R. Bartenschlager, Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus, Hepatology, 2007, 46 (2): p. 330-338.

 


Phil Biggin

Whitfield, T., A.J. Miles, J.C. Scheinost, J. Offer, P. Wentworth, Jr., R.A. Dwek, B.A. Wallace, P.C. Biggin and N. Zitzmann, The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein, Mol Membr Biol, 2011, 28 (5): p. 254-264.

 

Chew, C.F., R. Vijayan, J. Chang, N. Zitzmann and P.C. Biggin, Determination of pore-lining residues in the hepatitis C virus p7 protein, Biophys J, 2009, 96 (2): p. L10-12.

 

Luik, P., C. Chew, J. Aittoniemi, J. Chang, P. Wentworth, Jr., R.A. Dwek, P.C. Biggin, C. Venien-Bryan and N. Zitzmann, The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy, Proc Natl Acad Sci U S A, 2009, 106 (31): p. 12712-12716.

 

 

Baruch Blumberg

Pavlovic, D., D.C. Neville, O. Argaud, B. Blumberg, R.A. Dwek, W.B. Fischer and N. Zitzmann, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives, Proc Natl Acad Sci U S A, 2003, 100 (10): p. 6104-6108.

 

Zitzmann, N., A.S. Mehta, S. Carrouee, T.D. Butters, F.M. Platt, J. McCauley, B.S. Blumberg, R.A. Dwek and T.M. Block, Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents, Proc Natl Acad Sci U S A, 1999, 96 (21): p. 11878-11882.

 


Chris Boutell

Antrobus, R., K. Grant, B. Gangadharan, D. Chittenden, R.D. Everett, N. Zitzmann and C. Boutell, Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome, Proteomics, 2009, 9 (15): p. 3913-3927.

 

 

Carmen Capeans

Pardo, M., A. Pineiro, M. de la Fuente, A. Garcia, S. Prabhakar, N. Zitzmann, R.A. Dwek, M. Sanchez-Salorio, F. Dominguez and C. Capeans, Abnormal cell cycle regulation in primary human uveal melanoma cultures, J Cell Biochem, 2004, 93 (4): p. 708-720.

 

 

Wolfgang Fischer

Patargias, G., N. Zitzmann, R. Dwek and W.B. Fischer, Protein-protein interactions: modeling the hepatitis C virus ion channel p7, J Med Chem, 2006, 49 (2): p. 648-655.

 

Pavlovic, D., W. Fischer, M. Hussey, D. Durantel, S. Durantel, N. Branza-Nichita, S. Woodhouse, R.A. Dwek and N. Zitzmann, Long alkylchain iminosugars block the HCV p7 ion channel, Adv Exp Med Biol, 2005, 564 p. 3-4.

 

Pavlovic, D., D.C. Neville, O. Argaud, B. Blumberg, R.A. Dwek, W.B. Fischer and N. Zitzmann, The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives, Proc Natl Acad Sci U S A, 2003, 100 (10): p. 6104-6108.

 


Eva Harris

Miller, J.L., R. Lachica, A.C. Sayce, J.P. Williams, M. Bapat, R. Dwek, P.R. Beatty, E. Harris and N. Zitzmann, Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo, Antimicrob Agents Chemother, 2012, 56 (12): p. 6379-6386.

 


David Harvey

Behrens A.J., S. Vasiljevic, L.K. Pritchard, D.J. Harvey, R.S. Andev, S.A. Krumm, W.B. Struwe, A. Cupo, A. Kumar, N. Zitzmann, G.E. Seabright, H.B. Kramer, D.I.R. Spencer, L. Royle, J.H. Lee, P.J. Klasse, D.R. Burton, I.A. Wilson, A.B. Ward, R.W. Sanders, J.P. Moore, K.J. Doores, and M. Crispin, Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein, Cell Rep, 2016, 14 (11): p. 2695-2706.

 

Abd Hamid, U.M., L. Royle, R. Saldova, C.M. Radcliffe, D.J. Harvey, S.J. Storr, M. Pardo, R. Antrobus, C.J. Chapman, N. Zitzmann, J.F. Robertson, R.A. Dwek and P.M. Rudd, A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression, Glycobiology, 2008, 18 (12): p. 1105-1118.

 

Scanlan, C.N., G.E. Ritchie, K. Baruah, M. Crispin, D.J. Harvey, B.B. Singer, L. Lucka, M.R. Wormald, P. Wentworth, Jr., N. Zitzmann, P.M. Rudd, D.R. Burton and R.A. Dwek, Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody, J Mol Biol, 2007, 372 (1): p. 16-22.

 

 

Atsushi Kato

Kato, A., Y. Hirokami, K. Kinami, Y. Tsuji, S. Miyawaki, I. Adachi, J. Hollinshead, R.J. Nash, J. Kiappes, N. Zitzmann, J.K. Cha, R.J. Molyneux, G.W.J. Fleet and N. Asano, Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors, Phytochemistry, 2015, 111, p. 124-131.

 

 

Paul Klenerman

van Wilgenburg B., I. Scherwitzl, E.C. Hutchinson, T. Leng, A. Kurioka, C. Kulicke, C. de Lara, S. Cole, S. Vasanawathana, W. Limpitikul, P. Malasit, D. Young, L. Denney, STOP-HCV consortium (E. Barnes, J. Ball, G. Burgess, G. Cooke, J. Dillon, C. Gore, G. Foster, N. Guha, R. Halford, C. Herath, C. Holmes, A. Howe, E. Hudson, W. Irving, S. Khakoo, D. Koletzki, N. Martin, T. Mbisa, J. McKeating, J. McLauchlan, A. Miners, A. Murray, P. Shaw, P. Simmonds, C. Spencer, P. Targett-Adams, E. Thomson, P. Vickerman, N. Zitzmann), M.D. Moore, P. Fabris, M.T. Giordani, Y.H. Oo, S.M. Laidlaw, L.B. Dustin, L.P. Ho, F.M. Thompson, N. Ramamurthy, J. Mongkolsapaya, C.B. Willberg, G.R. Screaton and P. Klenerman, MAIT cells are activated during human viral infections, Nat Commun, 2016, 7, p. 11653.

 

Gangadharan, B., M. Bapat, J. Rossa, R. Antrobus, D. Chittenden, B. Kampa, E. Barnes, P. Klenerman, R.A. Dwek and N. Zitzmann, Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study, PLoS One, 2012, 7 (6): p. e39603.

 

Gangadharan, B., R. Antrobus, D. Chittenden, J. Rossa, M. Bapat, P. Klenerman, E. Barnes, R.A. Dwek and N. Zitzmann, New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients, J Proteome Res, 2011, 10 (5): p. 2643-2650.

 

Billerbeck, E., Y.H. Kang, L. Walker, H. Lockstone, S. Grafmueller, V. Fleming, J. Flint, C.B. Willberg, B. Bengsch, B. Seigel, N. Ramamurthy, N. Zitzmann, E.J. Barnes, J. Thevanayagam, A. Bhagwanani, A. Leslie, Y.H. Oo, S. Kollnberger, P. Bowness, O. Drognitz, D.H. Adams, H.E. Blum, R. Thimme and P. Klenerman, Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties, Proc Natl Acad Sci U S A, 2010, 107 (7): p. 3006-3011.

 

Woodhouse, S.D., R. Narayan, S. Latham, S. Lee, R. Antrobus, B. Gangadharan, S. Luo, G.P. Schroth, P. Klenerman and N. Zitzmann, Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro, Hepatology, 2010, 52 (2): p. 443-453.

 


Jane McKeating

Meredith, L.W., N. Zitzmann and J.A. McKeating, Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission, Antiviral Res, 2013, 100(3): p. 636-639.

 

Chan-Fook, C., W.R. Jiang, B.E. Clarke, N. Zitzmann, C. Maidens, J.A. McKeating and I.M. Jones, Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity, Virology, 2000, 273 (1): p. 60-66.

 


Andrew McMichael

Simmons, A., B. Gangadharan, A. Hodges, K. Sharrocks, S. Prabhakar, A. Garcia, R. Dwek, N. Zitzmann and A. McMichael, Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling, Immunity, 2005, 23 (6): p. 621-634.

 


Stefana Petrescu

Macovei, A., C. Radulescu, C. Lazar, S. Petrescu, D. Durantel, R.A. Dwek, N. Zitzmann and N.B. Nichita, Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells, J Virol, 2010, 84 (1): p. 243-253.

 

Block, T.M., A.S. Mehta, P.M. Rudd, M.R. Wormald, D.R. Burton, I.A. Wilson, S.M. Petrescu, F.M. Platt, N. Zitzmann, T.D. Butters and R.A. Dwek, Glycobiology - discovery, diagnostics and drugs, Scion Publishing Ltd, UK, 2007.

 

Popescu, C.I., A. Mares, L. Zdrentu, N. Zitzmann, R.A. Dwek and S.M. Petrescu, Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor, J Biol Chem, 2006, 281 (31): p. 21682-21689.

 


Thomas Pietschmann

Walter S., A. Bollenbach, J. Doerrbecker, S. Pfaender, R. Brown, G. Vieyres, C. Scott, R. Foster, A. Kumar, N. Zitzmann, S. Griffin, F. Penin, T. Pietschmann and E. Steinmann, Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7, J Virol, 2016, 90, p. 5075-5089.

 

Steinmann, E., T. Whitfield, S. Kallis, R.A. Dwek, N. Zitzmann, T. Pietschmann and R. Bartenschlager, Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus, Hepatology, 2007, 46 (2): p. 330-338.

 

 

Paul Rainey

Knight, C.G., X. Zhang, A. Gunn, T. Brenner, R.W. Jackson, S.R. Giddens, S. Prabhakar, N. Zitzmann and P.B. Rainey, Testing temperature-induced proteomic changes in the plant-associated bacterium Pseudomonas fluorescens SBW25, Environ Microbiol, 2010, 3 (2): p. 396-402.

 

Knight, C.G., N. Zitzmann, S. Prabhakar, R. Antrobus, R. Dwek, H. Hebestreit and P.B. Rainey, Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network, Nat Genet, 2006, 38 (9): p. 1015-1022.

 

 

Alison Simmons

Simmons, A., B. Gangadharan, A. Hodges, K. Sharrocks, S. Prabhakar, A. Garcia, R. Dwek, N. Zitzmann and A. McMichael, Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling, Immunity, 2005, 23 (6): p. 621-634.

 

 

Michael Stumpf

Stumpf, M.P. and N. Zitzmann, RNA replication kinetics, genetic polymorphism and selection in the case of the hepatitis C virus, Proc Biol Sci, 2001, 268 (1480): p. 1993-1999.

 

 

Catherine Vénien-Bryan

Luik, P., C. Chew, J. Aittoniemi, J. Chang, P. Wentworth, Jr., R.A. Dwek, P.C. Biggin, C. Venien-Bryan and N. Zitzmann, The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy, Proc Natl Acad Sci U S A, 2009, 106 (31): p. 12712-12716.

 

 

Bonnie Wallace

Whitfield, T., A.J. Miles, J.C. Scheinost, J. Offer, P. Wentworth, Jr., R.A. Dwek, B.A. Wallace, P.C. Biggin and N. Zitzmann, The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein, Mol Membr Biol, 2011, 28 (5): p. 254-264.

 


Steve Watson

Senis, Y.A., R. Antrobus, S. Severin, A.F. Parguina, I. Rosa, N. Zitzmann, S.P. Watson and A. Garcia, Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions, J Thromb Haemost, 2009, 7 (10): p. 1718-1726.

 

Senis, Y.A., M.G. Tomlinson, A. Garcia, S. Dumon, V.L. Heath, J. Herbert, S.P. Cobbold, J.C. Spalton, S. Ayman, R. Antrobus, N. Zitzmann, R. Bicknell, J. Frampton, K.S. Authi, A. Martin, M.J. Wakelam and S.P. Watson, A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein, Mol Cell Proteomics, 2007, 6 (3): p. 548-564.

 

Garcia, A., Y.A. Senis, R. Antrobus, C.E. Hughes, R.A. Dwek, S.P. Watson and N. Zitzmann, A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter, Proteomics, 2006, 6 (19): p. 5332-5343.

 

Senis, Y.A., P.Y. Kim, G.L. Fuller, A. Garcia, S. Prabhakar, M.C. Wilkinson, H. Brittan, N. Zitzmann, R. Wait, D.A. Warrell, S.P. Watson, A.S. Kamiguti, R.D. Theakston, M.E. Nesheim and G.D. Laing, Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara, Biochim Biophys Acta, 2006, 1764 (5): p. 863-871.

 

Suzuki-Inoue, K., G.L. Fuller, A. Garcia, J.A. Eble, S. Pohlmann, O. Inoue, T.K. Gartner, S.C. Hughan, A.C. Pearce, G.D. Laing, R.D. Theakston, E. Schweighoffer, N. Zitzmann, T. Morita, V.L. Tybulewicz, Y. Ozaki and S.P. Watson, A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2, Blood, 2006, 107 (2): p. 542-549.

 

Garcia, A., S.P. Watson, R.A. Dwek and N. Zitzmann, Applying proteomics technology to platelet research, Mass Spectrom Rev, 2005, 24 (6): p. 918-930.

 

Garcia, A., S. Prabhakar, S. Hughan, T.W. Anderson, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit and N. Zitzmann, Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins, Blood, 2004, 103 (6): p. 2088-2095.

 

Garcia, A., S. Prabhakar, C.J. Brock, A.C. Pearce, R.A. Dwek, S.P. Watson, H.F. Hebestreit and N. Zitzmann, Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry, Proteomics, 2004, 4 (3): p. 656-668.

 

Garcia, A., N. Zitzmann and S.P. Watson, Analyzing the platelet proteome, Semin Thromb Hemost, 2004, 30 (4): p. 485-489.

 


Paul Wentworth

Whitfield, T., A.J. Miles, J.C. Scheinost, J. Offer, P. Wentworth, Jr., R.A. Dwek, B.A. Wallace, P.C. Biggin and N. Zitzmann, The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein, Mol Membr Biol, 2011, 28 (5): p. 254-264.

 

Luik, P., C. Chew, J. Aittoniemi, J. Chang, P. Wentworth, Jr., R.A. Dwek, P.C. Biggin, C. Venien-Bryan and N. Zitzmann, The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy, Proc Natl Acad Sci U S A, 2009, 106 (31): p. 12712-12716.

 

Scanlan, C.N., G.E. Ritchie, K. Baruah, M. Crispin, D.J. Harvey, B.B. Singer, L. Lucka, M.R. Wormald, P. Wentworth, Jr., N. Zitzmann, P.M. Rudd, D.R. Burton and R.A. Dwek, Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody, J Mol Biol, 2007, 372 (1): p. 16-22.